it is all up with - meaning and definition. What is it is all up with
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What (who) is it is all up with - definition

ALBUM BY JAMES
Getting Away with It (All Messed Up); Getting Away With It (All Messed Up)

it is all up with      
informal
it is the end or there is no hope for.
So It Is         
2017 ALBUM
Draft:So It Is
So It Is is a studio album by the Preservation Hall Jazz Band of New Orleans, Louisiana. It was released on April 21, 2017 on Legacy Recordings, produced by TV On the Radio's Dave Sitek and Ben Jaffe, and recorded at Sonic Ranch in Tornillo, TX.
American Slavery As It Is         
BOOK BY THEODORE DWIGHT WELD
American Slavery As It Is: Testimony of a Thousand Witnesses; American Slavery as It Is: Testimony of a Thousand Witnesses; American Slavery as It Is
American Slavery as It Is: Testimony of a Thousand Witnesses is a book written by the American abolitionist Theodore Dwight Weld, his wife Angelina Grimké, and her sister Sarah Grimké, which was published in 1839.

Wikipedia

Pleased to Meet You (James album)

Pleased to Meet You is the ninth studio album by English rock band James. Less than a year after the release of Millionaires (1999), the band were playing new material live. Recording was split between Ridge Farm, Whitfield St., House in the Woods studios; producer credit was split between Brian Eno, guitarist/violinist Saul Davies, KK and the band. "Getting Away with It (All Messed Up)" was released as a single in late June, followed a week later by Pleased to Meet You on 2 July through Mercury Records.

The front cover features a composite image of all the band members' faces. Pleased to Meet You reached number 11 on the UK album chart, and was certified silver by the BPI. Lead single "Getting Away with It (All Messed Up)" reached number 22 on the UK singles chart. The record received a mainly favourable response from music critics. It was promoted with an appearance on Top of the Pops and various festivals across three months in the UK, Spain and Portugal. Vocalist Tim Booth left the band after their December UK tour; the final show of which was released as the Getting Away with It...Live live/video album in early 2002.

Examples of use of it is all up with
1. Fleet Street has long since convinced itself that it is all up with the War Criminal of Baghdad, one last push and he will be gone, taking John Prescott with him and opening up a promising new chapter: Brown v David Cameron.